Epiphone guitars are built with varying degrees of craftsmanship and quality, ranging from entry-level models to higher-end offerings. Squier guitars are usually entry-level and so made with more affordable materials and parts with the quality varying across models.Epiphone guitars are known for their replicas of Gibson’s classic designs like the Les Paul and SG but also produce their own unique models. Squier guitars are mainly designed to replicate Fender’s iconic models like the Stratocaster and Telecaster.The Main Differences Between Squier vs Epiphone The Main Differences Between Squier vs Epiphone.